منابع مشابه
Autoimmune Myopathies: Where Do We Stand?
Autoimmune diseases (AIDs) as a whole represent a major health concern and remain a medical and scientific challenge. Some of them, such as multiple sclerosis or type 1 diabetes, have been actively investigated for many decades. Autoimmune myopathies (AIMs), also referred to as idiopathic inflammatory myopathies or myositis, represent a group of very severe AID for which we have a more limited ...
متن کاملI-7 Autoimmune Inflammatory Myopathies: Summary on Pathogenesis and Therapies
Mitochondrial disorders (MDs) are caused by impairment of the mitochondrial electron transport chain (ETC). The ETC is needed for oxidative phosphorylation, which provides the cell with the most efficient energy outcome in terms of ATP production. One of the pathogenic mechanisms of MDs is the generation of reactive oxygen species. Potential pharmacological approaches for MDs include ETC cofact...
متن کاملAnti-HMGCR Autoantibodies in European Patients With Autoimmune Necrotizing Myopathies
Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-exposed patients. Here we report what is to our knowledge the first European coh...
متن کاملNecrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies
Idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the United States. Necrotizing autoimmune myopathy comprises only 16% of this group. It usually presents with severe proximal weakness, lower extremity weakness, and severe fatigue while very rarely does it present with dysphagia and respiratory muscle weakness. Statin use, canc...
متن کاملReview: An update on inflammatory and autoimmune myopathies.
The review provides an update on the diagnosis of the main subtypes of inflammatory myopathies including dermatomyositis (DM), polymyositis (PM), necrotizing autoimmune myositis (NAM) and sporadic inclusion body myositis (sIBM). The fundamental aspects on muscle pathology and the unique pathomechanisms of each subset are outlined and the diagnostic dilemmas concerning the distinction of PM from...
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ژورنال
عنوان ژورنال: CONTINUUM: Lifelong Learning in Neurology
سال: 2016
ISSN: 1080-2371
DOI: 10.1212/01.con.0000511070.50715.ab